Fast jag har läst om många positiva fördelar med "brunt fett" och inte bara på halleluja sidor....
Additionally research has shown:
Brown adipose tissue activation improves glucose homeostasis and insulin sensitivity in humans suggesting that anyone with impaired insulin function might benefit from BAT activation, however there is broader application given research showing even mildly elevated blood glucose in healthy non-diabetic humans is associated with damage over time of many organs such as eyes, tendons, endothelial/cardiovascular system and brain, and results in higher levels of damaging advanced glycation end products.
Brown adipose tissue activation may play an important role in bone health and bone density.
Brown adipose tissue activation through cold exposure increases adiponectin levels, just two hours of cold exposure resulted in a 70% increase in circulating adiponectin in adult men. Centenarians (both men and women) and their offspring have been found to have genetics that boost adiponectin, and they have higher circulating adiponectin, suggesting a link between longevity and adiponectin production In addition, high concentrations of plasma adiponectin in centenarians was associated with favorable metabolic indicators, and with lower levels of C-reactive protein and E-selectin.
Cold exposure increases circulating irisin. Irisin improves insulin sensitivity, increases bone quality and quantity, is involved in the building of lean muscle mass, and helps reduce obesity by converting white fat to brown fat, providing many of the same benefits of exercise. Healthy centenarians are characterized by increased serum irisin levels, whereas levels of this hormone were found to be significantly lower in young patients with myocardial infarction. These findings may prompt further research into the role played by irisin not only in vascular disorders but also in life span modulation.
Fibroblast Growth Factor 21 Production (FGF-21) has been documented as a pathway to longevity. BAT activation through cold exposure up-regulates circulating fibroblast growth factor 21 (FGF21) in humans by 37%. FGF21 improves insulin sensitivity and glucose metabolism which may partially explain its longevity promoting benefits.
Under basal environmental temperatures, HDAC3 primes expression of UCP1 and the brown fat thermogenic program to ensure acute cold survival through the deacetylation and activation of PGC-1alpha.
Cold exposure increases SIRT1 phosphorylation/activity in both skeletal muscle and BAT, increasing thermogenesis and insulin sensitivity through deacetylation of PGC-1alpha and other protein targets. Elevated SIRT1 levels in people are associated with increased human longevity. SIRT1 (and the other sirtuins) have many metabolic effects, but an important one for improving health and longevity is the fact that SIRT1 increases insulin sensitivity and glucose control in skeletal muscles, triggers the browning of white fat and increases BAT activity.
Intermittent fasting (especially EODF or every-other-day-fasting) promotes white adipose browning and decreases obesity by shaping the gut microbiota, and reverses high-fat-diet-induced obesity and associated metabolic disorders.