Malte Ritzén

Strikt ketogen kost & hjärntumör

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Hej igen 

Jag lägger upp en kopia av dokumentet här så alla kan ta del av det. Skrev detta för ett antal år sedan så passade på att uppdatera en del referenser då hypotesen har stärkts baserat på senaste årens forskning (den tidigare verisionen tror jag också finns postad här på forumet för några år sedan). 

 

Novel hypothesis to cure cancer through therapeutic hypoglycemia

1.       Increase ketone concentration (β-hydroxybutyrate & Acetoacetate), either endogenous (ketogenic diet/fasting) and/or exogenous (ingestion of ketone salt/ester or IV administration)

2.       Induce therapeutic hypoglycemia. There are a number of existing drugs that can decrease blood glucose. Metformin might be the first choice to slowly decrease blood glucose during some weeks. For a more dramatic and acute intervention insulin can be used. Cancer starvation should lead cell apoptosis or at least a profoundly depressed metabolism. Be aware, insulin will also decrease β-hydroxybutyrate (AcAc is less sensitive to insulin). The sum of glucose and ketone bodies should to be at least 4 mmol/L to avoid brain damage.

 

References

A)      Ketones suppress cancer cells

Cell Death Dis. 2019 Mar

p53 β-hydroxybutyrylation attenuates p53 activity

Kun Liu, Fangzhou Li, Qianqian Sun, Ning Lin, Haichao Han, Kaiqiang You, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Meiyu Geng, Yingming Zhao, Wei Gu, and Wenhui Zhaocorresponding

 

Int J Cancer. 2014 Oct

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer.

Poff AM, Ari C, Arnold P, Seyfried TN, D'Agostino DP.

http://www.ncbi.nlm.nih.gov/pubmed/24615175

 

B)       Low glucose concentration can starve the cancer cells

J Exp Clin Cancer Res. 2019 Feb

Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways.

Ma L, Wei J, Wan J, Wang W, Wang L, Yuan Y, Yang Z, Liu X, Ming L.

 

J Exp Clin Cancer Res. 2019 Feb

Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways.

Ma L, Wei J, Wan J, Wang W, Wang L, Yuan Y, Yang Z, Liu X, Ming L

 

Cureus. 2015 Feb

The Efficacy of Ketogenic Diet and Associated Hypoglycemia as an Adjuvant Therapy for High-Grade Gliomas: A Review of the Literature.

Varshneya K, Carico C, Ortega A, Patil CG

 

Med Hypotheses. 2014 Dec 10

Starvation of cancer via induced ketogenesis and severe hypoglycemia.

Kapelner A, Vorsanger M.

http://www.ncbi.nlm.nih.gov/pubmed/25579853

 

Nutrition. 2014 Feb

Tumor cell culture survival following glucose and glutamine deprivation at typical physiological concentrations.

Mathews EH, Stander BA, Joubert AM, Liebenberg L.

http://www.ncbi.nlm.nih.gov/pubmed/24262514

 

Cell Cycle. Mar 1, 2013

A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene

The Atkins diet suppresses tumor growth

Edward L. LaGory and Amato J. Giaccia*

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610718/

 

PLoS One. 2013 Jun

The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.

Poff AM, Ari C, Seyfried TN, D'Agostino DP.

http://www.ncbi.nlm.nih.gov/pubmed/23755243

 

Drug Resist Updat. 2012 Feb-Apr

Starvation, detoxification, and multidrug resistance in cancer therapy

Changhan Lee,a, Lizzia Raffaghello,b and Valter D. Longoa

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573885/

 

 

C)       The CNS can survive hypoglycemia

 

J Clin Endocrinol Metab. 2014 Nov

Systemic, cerebral and skeletal muscle ketone body and energy metabolism during acute hyper-D-β-hydroxybutyrataemia in post-absorptive healthy males.

Mikkelsen KH, Seifert T, Secher NH, Grøndal T, van Hall G.

http://www.ncbi.nlm.nih.gov/pubmed/25415176

 

Endocr Pract. 2010 Sep-Oct

Insulinoma in a patient with normal results from prolonged fast and glucagon-induced hypoglycemia.

Soh AW, Kek PC.

http://www.ncbi.nlm.nih.gov/pubmed/20570814

 

Am J Emerg Med. 1997 May

Alcoholic ketoacidosis presenting with extreme hypoglycemia.

Marinella MA

https://www.ncbi.nlm.nih.gov/pubmed/9148987

 

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