Sanitas_Source Posted December 27, 2012 Share Posted December 27, 2012 Vad vet ni om lipoprotein lipase och hormone sensitive lipase och deras effekt på vår reglering av lagrat fett? Gary Taubes påstår att insulinets påverkan på dessa två enzymer är en av huvudanledningarna till att vi blir feta, det tillsammans med insulinresistans och ett par andra faktorer. Eller har jag förståt honom fel? Vh Stefan Sandberg Lic. Kostrådgivare Quote Link to comment Share on other sites More sharing options...
Gunilla_P Posted April 25, 2013 Share Posted April 25, 2013 Hej! Du har säkert sett på youTuben: "The Skinny on Obesity" with Dr. Lustig :Det finns mer klipp på hur fruktos påverkar i kroppen av honom. Quote Link to comment Share on other sites More sharing options...
Zepp Posted May 1, 2013 Share Posted May 1, 2013 Vad vet ni om lipoprotein lipase och hormone sensitive lipase och deras effekt på vår reglering av lagrat fett? Gary Taubes påstår att insulinets påverkan på dessa två enzymer är en av huvudanledningarna till att vi blir feta, det tillsammans med insulinresistans och ett par andra faktorer. Eller har jag förståt honom fel? Vh Stefan Sandberg Lic. Kostrådgivare Näe du har inte förstått honom fel.. insulin är den främsta regulatorn av esterifieringen och reesterifieringen av triglycerider. "LPL isozymes are regulated differently depending on the tissue. For example, insulin is known to activate LPL in adipocytes and its placement in the capillary endothelium. By contrast, insulin has been shown to decrease expression of muscle LPL.[18] Muscle andmyocardial LPL is instead activated by glucagon and adrenaline. This helps to explain why during fasting, LPL activity increases in muscle tissue and decreases in adipose tissue, whereas after a meal, the opposite occurs.[1][8] Consistent with this, dietary macronutrients differentially affect adipose and muscle LPL activity. After 16 days on a high-carbohydrate or a high-fat diet, LPL activity increased significantly in both tissues 6 hours after a meal of either composition, but there was a significantly greater rise in adipose tissue LPL in response to the high-carbohydrate diet compared to the high-fat diet. There was no difference between the two diets' effects on or insulin sensitivity, or on fasting LPL activity in either tissue." http://en.wikipedia.org/wiki/Lipoprotein_lipase "HSL is activated when the body needs to mobilize energy stores, and so responds positively to catecholamines, ACTH. It is inhibited by insulin. Previously, glucagon was thought to activate HSL, however the removal of insulin's inhibitory effects ("cutting the brakes") is the source of activation." http://en.wikipedia.org/wiki/Hormone-sensitive_lipase Quote Link to comment Share on other sites More sharing options...
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