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Vad vet ni om lipoprotein lipase och hormone sensitive lipase och deras effekt på vår reglering av lagrat fett? Gary Taubes påstår att insulinets påverkan på dessa två enzymer är en av huvudanledningarna till att vi blir feta, det tillsammans med insulinresistans och ett par andra faktorer.

 

Eller har jag förståt honom fel?

 

Vh Stefan Sandberg

Lic. Kostrådgivare

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  • 3 months later...

Vad vet ni om lipoprotein lipase och hormone sensitive lipase och deras effekt på vår reglering av lagrat fett? Gary Taubes påstår att insulinets påverkan på dessa två enzymer är en av huvudanledningarna till att vi blir feta, det tillsammans med insulinresistans och ett par andra faktorer.

 

Eller har jag förståt honom fel?

 

Vh Stefan Sandberg

Lic. Kostrådgivare

Näe du har inte förstått honom fel.. insulin är den främsta regulatorn av esterifieringen och reesterifieringen av triglycerider.

 

"LPL isozymes are regulated differently depending on the tissue. For example, insulin is known to activate LPL in adipocytes and its placement in the capillary endothelium. By contrast, insulin has been shown to decrease expression of muscle LPL.[18] Muscle andmyocardial LPL is instead activated by glucagon and adrenaline. This helps to explain why during fasting, LPL activity increases in muscle tissue and decreases in adipose tissue, whereas after a meal, the opposite occurs.[1][8]

Consistent with this, dietary macronutrients differentially affect adipose and muscle LPL activity. After 16 days on a high-carbohydrate or a high-fat diet, LPL activity increased significantly in both tissues 6 hours after a meal of either composition, but there was a significantly greater rise in adipose tissue LPL in response to the high-carbohydrate diet compared to the high-fat diet. There was no difference between the two diets' effects on or insulin sensitivity, or on fasting LPL activity in either tissue."

 

http://en.wikipedia.org/wiki/Lipoprotein_lipase

 

"HSL is activated when the body needs to mobilize energy stores, and so responds positively to catecholaminesACTH. It is inhibited by insulin. Previously, glucagon was thought to activate HSL, however the removal of insulin's inhibitory effects ("cutting the brakes") is the source of activation."

http://en.wikipedia.org/wiki/Hormone-sensitive_lipase

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