Popular Post Johanna07 Posted November 12, 2015 Popular Post Share Posted November 12, 2015 A research project led by Associate Professor Zoltan Sarnyai of the Centre for Bioodiscovery and Molecular Development of Therapeutics suggests that the high-fat/low-carb ketogenic diet may be effective in the management of schizophrenia. Schizophrenia is a devastating, chronic mental illness that affects close to one percent of the population worldwide. It is characterised by hallucinations (hearing voices), delusions (unshakable beliefs in something untrue), social withdrawal and problems with thinking, causing suffering for the patient and major challenges to their families. At present there is no cure for schizophrenia. The medications used only target some of the symptoms and they produce side effects such as movement disorder, weight gain and cardiovascular disease in the long-term, prompting the need to develop more effective treatment with fewer side effects. A group at James Cook University, Australia, led by Associate Professor Zoltan Sarnyai has discovered that feeding mice with ketogenic diet, which is high on fat but very low on carbohydrates (sugars), leads to the normalisation of behaviours that resembles to schizophrenia in a well-established animal model of the disorder. Their work, published online in the leading journal Schizophrenia Research, also show that mice on ketogenic diet weight less and have lower blood glucose levels than mice fed with normal mouse diet. Dr. Sarnyai believes that ketogenic diet might work by providing alternative energy sources in the form of so-called ketone bodies (products of fat breakdown) and by helping to circumvent abnormally functioning cellular energy pathways in the brain in schizophrenia. The ketogenic diet has been used since the 1920’s to manage epilepsy in children and more recently as a weight loss diet preferred by some body builders. If this intriguing novel finding is replicated in other animal models it can be swiftly translated into an effective management of schizophrenia, which will hopefully not only alleviate the symptoms but it may also be able to counteract the unwanted weight-related side-effects of currently used anti-schizophrenia drugs. https://research.jcu.edu.au/bmdt/publications-the-ketogenic-diet-and-schizophrenia 8 Quote Link to comment Share on other sites More sharing options...
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